RT Journal Article SR Electronic T1 Soft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays JF Science Advances JO Sci Adv FD American Association for the Advancement of Science SP eaap9841 DO 10.1126/sciadv.aap9841 VO 4 IS 1 A1 Park, Jihun A1 Kim, Joohee A1 Kim, So-Yun A1 Cheong, Woon Hyung A1 Jang, Jiuk A1 Park, Young-Geun A1 Na, Kyungmin A1 Kim, Yun-Tae A1 Heo, Jun Hyuk A1 Lee, Chang Young A1 Lee, Jung Heon A1 Bien, Franklin A1 Park, Jang-Ung YR 2018 UL http://advances.sciencemag.org/content/4/1/eaap9841.abstract AB Recent advances in wearable electronics combined with wireless communications are essential to the realization of medical applications through health monitoring technologies. For example, a smart contact lens, which is capable of monitoring the physiological information of the eye and tear fluid, could provide real-time, noninvasive medical diagnostics. However, previous reports concerning the smart contact lens have indicated that opaque and brittle components have been used to enable the operation of the electronic device, and this could block the user’s vision and potentially damage the eye. In addition, the use of expensive and bulky equipment to measure signals from the contact lens sensors could interfere with the user’s external activities. Thus, we report an unconventional approach for the fabrication of a soft, smart contact lens in which glucose sensors, wireless power transfer circuits, and display pixels to visualize sensing signals in real time are fully integrated using transparent and stretchable nanostructures. The integration of this display into the smart lens eliminates the need for additional, bulky measurement equipment. This soft, smart contact lens can be transparent, providing a clear view by matching the refractive indices of its locally patterned areas. The resulting soft, smart contact lens provides real-time, wireless operation, and there are in vivo tests to monitor the glucose concentration in tears (suitable for determining the fasting glucose level in the tears of diabetic patients) and, simultaneously, to provide sensing results through the contact lens display.