PT  - JOURNAL ARTICLE
AU  - Huang, Liang
AU  - Chen, Jinxing
AU  - Gan, Linfeng
AU  - Wang, Jin
AU  - Dong, Shaojun
TI  - Single-atom nanozymes
AID  - 10.1126/sciadv.aav5490
DP  - 2019 May 01
TA  - Science Advances
PG  - eaav5490
VI  - 5
IP  - 5
4099  - http://advances.sciencemag.org/content/5/5/eaav5490.short
4100  - http://advances.sciencemag.org/content/5/5/eaav5490.full
SO  - Sci Adv2019 May 01; 5
AB  - Conventional nanozyme technologies face formidable challenges of intricate size-, composition-, and facet-dependent catalysis and inherently low active site density. We discovered a new class of single-atom nanozymes with atomically dispersed enzyme-like active sites in nanomaterials, which significantly enhanced catalytic performance, and uncovered the underlying mechanism. With oxidase catalysis as a model reaction, experimental studies and theoretical calculations revealed that single-atom nanozymes with carbon nanoframe–confined FeN5 active centers (FeN5 SA/CNF) catalytically behaved like the axial ligand–coordinated heme of cytochrome P450. The definite active moieties and crucial synergistic effects endow FeN5 SA/CNF with a clear electron push-effect mechanism, as well as the highest oxidase-like activity among other nanozymes (the rate constant is 70 times higher than that of commercial Pt/C) and versatile antibacterial applications. These suggest that the single-atom nanozymes have great potential to become the next-generation nanozymes.