RT Journal Article
SR Electronic
T1 Unprecedented reorganization of holocentric chromosomes provides insights into the enigma of lepidopteran chromosome evolution
JF Science Advances
JO Sci Adv
FD American Association for the Advancement of Science
SP eaau3648
DO 10.1126/sciadv.aau3648
VO 5
IS 6
A1 Hill, Jason
A1 Rastas, Pasi
A1 Hornett, Emily A.
A1 Neethiraj, Ramprasad
A1 Clark, Nathan
A1 Morehouse, Nathan
A1 de la Paz Celorio-Mancera, Maria
A1 Cols, Jofre Carnicer
A1 Dircksen, Heinrich
A1 Meslin, Camille
A1 Keehnen, Naomi
A1 Pruisscher, Peter
A1 Sikkink, Kristin
A1 Vives, Maria
A1 Vogel, Heiko
A1 Wiklund, Christer
A1 Woronik, Alyssa
A1 Boggs, Carol L.
A1 Nylin, Sören
A1 Wheat, Christopher W.
YR 2019
UL http://advances.sciencemag.org/content/5/6/eaau3648.abstract
AB Chromosome evolution presents an enigma in the mega-diverse Lepidoptera. Most species exhibit constrained chromosome evolution with nearly identical haploid chromosome counts and chromosome-level gene collinearity among species more than 140 million years divergent. However, a few species possess radically inflated chromosomal counts due to extensive fission and fusion events. To address this enigma of constraint in the face of an exceptional ability to change, we investigated an unprecedented reorganization of the standard lepidopteran chromosome structure in the green-veined white butterfly (Pieris napi). We find that gene content in P. napi has been extensively rearranged in large collinear blocks, which until now have been masked by a haploid chromosome number close to the lepidopteran average. We observe that ancient chromosome ends have been maintained and collinear blocks are enriched for functionally related genes suggesting both a mechanism and a possible role for selection in determining the boundaries of these genome-wide rearrangements.