RT Journal Article
SR Electronic
T1 GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI
JF Science Advances
JO Sci Adv
FD American Association for the Advancement of Science
SP eaaw3095
DO 10.1126/sciadv.aaw3095
VO 5
IS 9
A1 Couto Alves, Alexessander
A1 De Silva, N. Maneka G.
A1 Karhunen, Ville
A1 Sovio, Ulla
A1 Das, Shikta
A1 Taal, H. Rob
A1 Warrington, Nicole M.
A1 Lewin, Alexandra M.
A1 Kaakinen, Marika
A1 Cousminer, Diana L.
A1 Thiering, Elisabeth
A1 Timpson, Nicholas J.
A1 Bond, Tom A.
A1 Lowry, Estelle
A1 Brown, Christopher D.
A1 Estivill, Xavier
A1 Lindi, Virpi
A1 Bradfield, Jonathan P.
A1 Geller, Frank
A1 Speed, Doug
A1 Coin, Lachlan J. M.
A1 Loh, Marie
A1 Barton, Sheila J.
A1 Beilin, Lawrence J.
A1 Bisgaard, Hans
A1 Bønnelykke, Klaus
A1 Alili, Rohia
A1 Hatoum, Ida J.
A1 Schramm, Katharina
A1 Cartwright, Rufus
A1 Charles, Marie-Aline
A1 Salerno, Vincenzo
A1 Clément, Karine
A1 Claringbould, Annique A. J.
A1 ,
A1 van Duijn, Cornelia M.
A1 Moltchanova, Elena
A1 Eriksson, Johan G.
A1 Elks, Cathy
A1 Feenstra, Bjarke
A1 Flexeder, Claudia
A1 Franks, Stephen
A1 Frayling, Timothy M.
A1 Freathy, Rachel M.
A1 Elliott, Paul
A1 Widén, Elisabeth
A1 Hakonarson, Hakon
A1 Hattersley, Andrew T.
A1 Rodriguez, Alina
A1 Banterle, Marco
A1 Heinrich, Joachim
A1 Heude, Barbara
A1 Holloway, John W.
A1 Hofman, Albert
A1 Hyppönen, Elina
A1 Inskip, Hazel
A1 Kaplan, Lee M.
A1 Hedman, Asa K.
A1 Läärä, Esa
A1 Prokisch, Holger
A1 Grallert, Harald
A1 Lakka, Timo A.
A1 Lawlor, Debbie A.
A1 Melbye, Mads
A1 Ahluwalia, Tarunveer S.
A1 Marinelli, Marcella
A1 Millwood, Iona Y.
A1 Palmer, Lyle J.
A1 Pennell, Craig E.
A1 Perry, John R.
A1 Ring, Susan M.
A1 Savolainen, Markku J.
A1 Rivadeneira, Fernando
A1 Standl, Marie
A1 Sunyer, Jordi
A1 Tiesler, Carla M. T.
A1 Uitterlinden, Andre G.
A1 Schierding, William
A1 O’Sullivan, Justin M.
A1 Prokopenko, Inga
A1 Herzig, Karl-Heinz
A1 Smith, George Davey
A1 O'Reilly, Paul
A1 Felix, Janine F.
A1 Buxton, Jessica L.
A1 Blakemore, Alexandra I. F.
A1 Ong, Ken K.
A1 Jaddoe, Vincent W. V.
A1 Grant, Struan F. A.
A1 Sebert, Sylvain
A1 McCarthy, Mark I.
A1 Järvelin, Marjo-Riitta
A1 ,
YR 2019
UL http://advances.sciencemag.org/content/5/9/eaaw3095.abstract
AB Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.