RT Journal Article SR Electronic T1 Red blood cell–derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy JF Science Advances JO Sci Adv FD American Association for the Advancement of Science SP eaaw6870 DO 10.1126/sciadv.aaw6870 VO 5 IS 10 A1 Han, Xiao A1 Shen, Shufang A1 Fan, Qin A1 Chen, Guojun A1 Archibong, Edikan A1 Dotti, Gianpietro A1 Liu, Zhuang A1 Gu, Zhen A1 Wang, Chao YR 2019 UL http://advances.sciencemag.org/content/5/10/eaaw6870.abstract AB Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery platform due to their inherent biocompatibility. Here, we developed an antigen delivery system based on the nanoerythrosomes derived from RBCs, inspired by the splenic antigen-presenting cell targeting capacity of senescent RBCs. Tumor antigens were loaded onto the nanoerythrosomes by fusing tumor cell membrane–associated antigens with nanoerythrosomes. This tumor antigen–loaded nanoerythrosomes (nano-Ag@erythrosome) elicited antigen responses in vivo and, in combination with the anti–programmed death ligand 1 (PD-L1) blockade, inhibited the tumor growth in B16F10 and 4T1 tumor models. We also generated a tumor model showing that “personalized nano-Ag@erythrosomes” could be achieved by fusing RBCs and surgically removed tumors, which effectively reduced tumor recurrence and metastasis after surgery.