RT Journal Article
SR Electronic
T1 Red blood cell–derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy
JF Science Advances
JO Sci Adv
FD American Association for the Advancement of Science
SP eaaw6870
DO 10.1126/sciadv.aaw6870
VO 5
IS 10
A1 Han, Xiao
A1 Shen, Shufang
A1 Fan, Qin
A1 Chen, Guojun
A1 Archibong, Edikan
A1 Dotti, Gianpietro
A1 Liu, Zhuang
A1 Gu, Zhen
A1 Wang, Chao
YR 2019
UL http://advances.sciencemag.org/content/5/10/eaaw6870.abstract
AB Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery platform due to their inherent biocompatibility. Here, we developed an antigen delivery system based on the nanoerythrosomes derived from RBCs, inspired by the splenic antigen-presenting cell targeting capacity of senescent RBCs. Tumor antigens were loaded onto the nanoerythrosomes by fusing tumor cell membrane–associated antigens with nanoerythrosomes. This tumor antigen–loaded nanoerythrosomes (nano-Ag@erythrosome) elicited antigen responses in vivo and, in combination with the anti–programmed death ligand 1 (PD-L1) blockade, inhibited the tumor growth in B16F10 and 4T1 tumor models. We also generated a tumor model showing that “personalized nano-Ag@erythrosomes” could be achieved by fusing RBCs and surgically removed tumors, which effectively reduced tumor recurrence and metastasis after surgery.