RT Journal Article SR Electronic T1 Time perception deficits and its dose-dependent effect in methamphetamine dependents with short-term abstinence JF Science Advances JO Sci Adv FD American Association for the Advancement of Science SP eaax6916 DO 10.1126/sciadv.aax6916 VO 5 IS 10 A1 Zhang, Mingming A1 Zhao, Di A1 Zhang, Zhao A1 Cao, Xinyu A1 Yin, Lu A1 Liu, Yi A1 Yuan, Ti-Fei A1 Luo, Wenbo YR 2019 UL http://advances.sciencemag.org/content/5/10/eaax6916.abstract AB Intake of addictive substances acutely modifies dopaminergic transmission in the striatum and prefrontal cortex, which is the neural substrate underlying time processing. However, the persistent effects of methamphetamine (meth) abuse (e.g., during abstinence) on temporal processing have not been fully elucidated. Here, we recruited different samples in two experiments. We first compared the potential differences in motor timing between healthy controls and meth dependents with varied length of abstinence and then examined the ability of perceptual timing between the healthy subjects and the meth group at short abstinence. We found that motor timing, but not perceptual timing, was altered in meth dependents, which persisted for at least 3 months of abstinence. Dose-dependent effects on time perception were only observed when short-term abstinent meth abusers processed long time intervals. We conclude that time perception alteration in meth dependents is task specific and dose dependent.