RT Journal Article
SR Electronic
T1 Targeted anti–IL-1β platelet microparticles for cardiac detoxing and repair
JF Science Advances
JO Sci Adv
FD American Association for the Advancement of Science
SP eaay0589
DO 10.1126/sciadv.aay0589
VO 6
IS 6
A1 Li, Zhenhua
A1 Hu, Shiqi
A1 Huang, Ke
A1 Su, Teng
A1 Cores, Jhon
A1 Cheng, Ke
YR 2020
UL http://advances.sciencemag.org/content/6/6/eaay0589.abstract
AB An acute myocardial infarction (AMI) induces a sterile inflammatory response that facilitates further heart injury and promotes adverse cardiac remodeling. Interleukin-1β (IL-1β) plays a central role in the sterile inflammatory response that results from AMI. Thus, IL-1β blockage is a promising strategy for treatment of AMI. However, conventional IL-1β blockers lack targeting specificity. This increases the risk of serious side effects. To address this problem herein, we fabricated platelet microparticles (PMs) armed with anti–IL-1β antibodies to neutralize IL-1β after AMI and to prevent adverse cardiac remodeling. Our results indicate that the infarct-targeting PMs could bind to the injured heart, increasing the number of anti–IL-1β antibodies therein. The anti–IL-1β platelet PMs (IL1-PMs) protect the cardiomyocytes from apoptosis by neutralizing IL-1β and decreasing IL-1β–driven caspase-3 activity. Our findings indicate that IL1-PM is a promising cardiac detoxification agent that removes cytotoxic IL-1β during AMI and induces therapeutic cardiac repair.