PT  - JOURNAL ARTICLE
AU  - He, Lizhen
AU  - Huang, Guanning
AU  - Liu, Hongxing
AU  - Sang, Chengcheng
AU  - Liu, Xinxin
AU  - Chen, Tianfeng
TI  - Highly bioactive zeolitic imidazolate framework-8–capped nanotherapeutics for efficient reversal of reperfusion-induced injury in ischemic stroke
AID  - 10.1126/sciadv.aay9751
DP  - 2020 Mar 01
TA  - Science Advances
PG  - eaay9751
VI  - 6
IP  - 12
4099  - http://advances.sciencemag.org/content/6/12/eaay9751.short
4100  - http://advances.sciencemag.org/content/6/12/eaay9751.full
SO  - Sci Adv2020 Mar 01; 6
AB  - Rational design of potent antioxidative agent with high biocompatibility is urgently needed to treat ischemic reperfusion-induced ROS-mediated cerebrovascular and neural injury during ischemia strokes. Here, we demonstrate an in situ synthetic strategy of bioactive zeolitic imidazolate framework-8–capped ceria nanoparticles (CeO2@ZIF-8 NPs) to achieve enhanced catalytic and antioxidative activities and improved stroke therapeutic efficacy. This nanosystem exhibits prolonged blood circulation time, reduced clearance rate, improved BBB penetration ability, and enhanced brain accumulation, where it effectively inhibits the lipid peroxidation in brain tissues in middle cerebral artery occlusion mice and reduces the oxidative damage and apoptosis of neurons in brain tissue. CeO2@ZIF-8 also suppresses inflammation- and immune response–induced injury by suppressing the activation of astrocytes and secretion of proinflammatory cytokines, thus achieving satisfactory prevention and treatment in neuroprotective therapy. This study also sheds light on the neuroprotective action mechanisms of ZIF-8–capped nanomedicine against reperfusion-induced injury in ischemic stroke.