PT - JOURNAL ARTICLE AU - He, Lizhen AU - Huang, Guanning AU - Liu, Hongxing AU - Sang, Chengcheng AU - Liu, Xinxin AU - Chen, Tianfeng TI - Highly bioactive zeolitic imidazolate framework-8–capped nanotherapeutics for efficient reversal of reperfusion-induced injury in ischemic stroke AID - 10.1126/sciadv.aay9751 DP - 2020 Mar 01 TA - Science Advances PG - eaay9751 VI - 6 IP - 12 4099 - http://advances.sciencemag.org/content/6/12/eaay9751.short 4100 - http://advances.sciencemag.org/content/6/12/eaay9751.full SO - Sci Adv2020 Mar 01; 6 AB - Rational design of potent antioxidative agent with high biocompatibility is urgently needed to treat ischemic reperfusion-induced ROS-mediated cerebrovascular and neural injury during ischemia strokes. Here, we demonstrate an in situ synthetic strategy of bioactive zeolitic imidazolate framework-8–capped ceria nanoparticles (CeO2@ZIF-8 NPs) to achieve enhanced catalytic and antioxidative activities and improved stroke therapeutic efficacy. This nanosystem exhibits prolonged blood circulation time, reduced clearance rate, improved BBB penetration ability, and enhanced brain accumulation, where it effectively inhibits the lipid peroxidation in brain tissues in middle cerebral artery occlusion mice and reduces the oxidative damage and apoptosis of neurons in brain tissue. CeO2@ZIF-8 also suppresses inflammation- and immune response–induced injury by suppressing the activation of astrocytes and secretion of proinflammatory cytokines, thus achieving satisfactory prevention and treatment in neuroprotective therapy. This study also sheds light on the neuroprotective action mechanisms of ZIF-8–capped nanomedicine against reperfusion-induced injury in ischemic stroke.