PT  - JOURNAL ARTICLE
AU  - Huang, Jianpan
AU  - van Zijl, Peter C. M.
AU  - Han, Xiongqi
AU  - Dong, Celia M.
AU  - Cheng, Gerald W. Y.
AU  - Tse, Kai-Hei
AU  - Knutsson, Linda
AU  - Chen, Lin
AU  - Lai, Joseph H. C.
AU  - Wu, Ed X.
AU  - Xu, Jiadi
AU  - Chan, Kannie W. Y.
TI  - Altered <span class="sc">d</span>-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI
AID  - 10.1126/sciadv.aba3884
DP  - 2020 May 01
TA  - Science Advances
PG  - eaba3884
VI  - 6
IP  - 20
4099  - http://advances.sciencemag.org/content/6/20/eaba3884.short
4100  - http://advances.sciencemag.org/content/6/20/eaba3884.full
SO  - Sci Adv2020 May 01; 6
AB  - Altered cerebral glucose uptake is one of the hallmarks of Alzheimer’s disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.