RT Journal Article
SR Electronic
T1 4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction
JF Science Advances
JO Sci Adv
FD American Association for the Advancement of Science
SP eabb5067
DO 10.1126/sciadv.abb5067
VO 6
IS 26
A1 Cui, Haitao
A1 Liu, Chengyu
A1 Esworthy, Timothy
A1 Huang, Yimin
A1 Yu, Zu-xi
A1 Zhou, Xuan
A1 San, Hong
A1 Lee, Se-jun
A1 Hann, Sung Yun
A1 Boehm, Manfred
A1 Mohiuddin, Muhammad
A1 Fisher, John P.
A1 Zhang, Lijie Grace
YR 2020
UL http://advances.sciencemag.org/content/6/26/eabb5067.abstract
AB There has been considerable progress in engineering cardiac scaffolds for the treatment of myocardial infarction (MI). However, it is still challenging to replicate the structural specificity and variability of cardiac tissues using traditional bioengineering approaches. In this study, a four-dimensional (4D) cardiac patch with physiological adaptability has been printed by beam-scanning stereolithography. By combining a unique 4D self-morphing capacity with expandable microstructure, the specific design has been shown to improve both the biomechanical properties of the patches themselves and the dynamic integration of the patch with the beating heart. Our results demonstrate improved vascularization and cardiomyocyte maturation in vitro under physiologically relevant mechanical stimulation, as well as increased cell engraftment and vascular supply in a murine chronic MI model. This work not only potentially provides an effective treatment method for MI but also contributes a cutting-edge methodology to enhance the structural design of complex tissues for organ regeneration.