PT  - JOURNAL ARTICLE
AU  - Devkota, Laxman
AU  - Starosolski, Zbigniew
AU  - Rivas, Charlotte H.
AU  - Stupin, Igor
AU  - Annapragada, Ananth
AU  - Ghaghada, Ketan B.
AU  - Parihar, Robin
TI  - Detection of response to tumor microenvironment–targeted cellular immunotherapy using nano-radiomics
AID  - 10.1126/sciadv.aba6156
DP  - 2020 Jul 01
TA  - Science Advances
PG  - eaba6156
VI  - 6
IP  - 28
4099  - http://advances.sciencemag.org/content/6/28/eaba6156.short
4100  - http://advances.sciencemag.org/content/6/28/eaba6156.full
SO  - Sci Adv2020 Jul 01; 6
AB  - Immunotherapies, including cell-based therapies, targeting the tumor microenvironment (TME) result in variable and delayed responses. Thus, it has been difficult to gauge the efficacy of TME-directed therapies early after administration. We investigated a nano-radiomics approach (quantitative analysis of nanoparticle contrast–enhanced three-dimensional images) for detection of tumor response to cellular immunotherapy directed against myeloid-derived suppressor cells (MDSCs), a key component of TME. Animals bearing human MDSC-containing solid tumor xenografts received treatment with MDSC-targeting human natural killer (NK) cells and underwent nanoparticle contrast–enhanced computed tomography (CT) imaging. Whereas conventional CT-derived tumor metrics were unable to differentiate NK cell immunotherapy tumors from untreated tumors, nano-radiomics revealed texture-based features capable of differentiating treatment groups. Our study shows that TME-directed cellular immunotherapy causes subtle changes not effectively gauged by conventional imaging metrics but revealed by nano-radiomics. Our work provides a method for noninvasive assessment of TME-directed immunotherapy potentially applicable to numerous solid tumors.