PT  - JOURNAL ARTICLE
AU  - Liu, Yufeng
AU  - Cheng, Yuan
AU  - Zhang, He
AU  - Zhou, Min
AU  - Yu, Yijun
AU  - Lin, Shichao
AU  - Jiang, Bo
AU  - Zhao, Xiaozhi
AU  - Miao, Leiying
AU  - Wei, Chuan-Wan
AU  - Liu, Quanyi
AU  - Lin, Ying-Wu
AU  - Du, Yan
AU  - Butch, Christopher J.
AU  - Wei, Hui
TI  - Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy
AID  - 10.1126/sciadv.abb2695
DP  - 2020 Jul 01
TA  - Science Advances
PG  - eabb2695
VI  - 6
IP  - 29
4099  - http://advances.sciencemag.org/content/6/29/eabb2695.short
4100  - http://advances.sciencemag.org/content/6/29/eabb2695.full
SO  - Sci Adv2020 Jul 01; 6
AB  - Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide dismutase by incorporation of a Mn–[5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato]–based metal-organic framework compound capable of transforming oxygen radicals to hydrogen peroxide. The second mimicked functionality is that of catalase by incorporation of Pt nanoparticles, which catalyze hydrogen peroxide disproportionation to water and oxygen. Both in vitro and in vivo experimental measurements reveal the synergistic ROS-scavenging capacity of such an integrated cascade nanozyme. Two forms of inflammatory bowel disease (IBD; i.e., ulcerative colitis and Crohn’s disease) can be effectively relieved by treatment with the cascade nanozyme. This study not only provides a new method for constructing enzyme-like cascade systems but also illustrates their efficient therapeutic promise in the treatment of in vivo IBDs.