RT Journal Article
SR Electronic
T1 Dissociation of broadband high-frequency activity and neuronal firing in the neocortex
JF Science Advances
JO Sci Adv
FD American Association for the Advancement of Science
SP eabb0977
DO 10.1126/sciadv.abb0977
VO 6
IS 33
A1 Leszczyński, Marcin
A1 Barczak, Annamaria
A1 Kajikawa, Yoshinao
A1 Ulbert, Istvan
A1 Falchier, Arnaud Y.
A1 Tal, Idan
A1 Haegens, Saskia
A1 Melloni, Lucia
A1 Knight, Robert T.
A1 Schroeder, Charles E.
YR 2020
UL http://advances.sciencemag.org/content/6/33/eabb0977.abstract
AB Broadband high-frequency activity (BHA; 70 to 150 Hz), also known as “high gamma,” a key analytic signal in human intracranial (electrocorticographic) recordings, is often assumed to reflect local neural firing [multiunit activity (MUA)]. As the precise physiological substrates of BHA are unknown, this assumption remains controversial. Our analysis of laminar multielectrode data from V1 and A1 in monkeys outlines two components of stimulus-evoked BHA distributed across the cortical layers: an “early-deep” and “late-superficial” response. Early-deep BHA has a clear spatial and temporal overlap with MUA. Late-superficial BHA was more prominent and accounted for more of the BHA signal measured near the cortical pial surface. However, its association with local MUA is weak and often undetectable, consistent with the view that it reflects dendritic processes separable from local neuronal firing.