RT Journal Article
SR Electronic
T1 Promoting the activation of T cells with glycopolymer-modified dendritic cells by enhancing cell interactions
JF Science Advances
JO Sci Adv
FD American Association for the Advancement of Science
SP eabb6595
DO 10.1126/sciadv.abb6595
VO 6
IS 47
A1 Yu, Liyin
A1 Feng, Ruyan
A1 Zhu, Lijuan
A1 Hao, Qing
A1 Chu, Jiacheng
A1 Gu, Yan
A1 Luo, Yan
A1 Zhang, Zexin
A1 Chen, Gaojian
A1 Chen, Hong
YR 2020
UL http://advances.sciencemag.org/content/6/47/eabb6595.abstract
AB Dendritic cell (DC) modification to enhance antigen presentation is a valuable strategy in cancer immune therapy. Other than focusing on regulating interactions between DC and antigens, we intend to promote cell interactions between DC and T cell by cell surface engineering. T cell activation is greatly improved and generates higher tumor toxicity with the aid of the synthetic glycopolymer modified on the DC surface, although the glycopolymer alone shows no effect. The great promotion of DC–T cell attraction is revealed by cell image tracking in terms of both frequency and duration of contacts. Our findings provide a new method of T cell activation by these engineered “sweet DCs.” This strategy is beneficial for developing more efficient DC-based vaccines.