Table 1 Chemical concentrations in water and medium, their corresponding predicted internal concentrations in fish gills (in vivo) and gill cells (in vitro), and their respective effects on fish and fish cell weight.
Concentration
in water
(mg/liter)
in FELS
Concentration
in fish gills
and gill cells
(μmol/g)
Concentration
in medium
(mg/liter)
in cell
proliferation
experiments
Fish
weight*
(% of
control)
Modeled
cell
weight
(% of
control)
Cyproconazole (log KOW = 2.9; molecular weight, 291.78 g/mol)
2.40.2961.5All dead47.9 (±9.62)
1.20.1480.7551.2 (±23.1)53.1 (±11.1)
0.60.0740.37570.9 (±15.6)66.4 (±15.9)
0.30.0370.187574.3 (±13.4)74.1 (±13.2)
0.150.0190.0937578.2 (±12.5)85.9 (±14.2)
Propiconazole (log KOW = 3.72; molecular weight, 342.22 g/mol)
1.00.4032.323.2 (±13.2)29.6 (±5.67)
0.50.2021.1574.1 (±22.3)60.5 (±8.62)
0.250.1010.57583.2 (±20.4)77.5 (±13.0)
0.1250.0500.287593.9 (±20.7)87.9 (±11.3)
0.06250.0250.1437596.1 (±24.6)93.6 (±11.8)

*Measured in FELS studies at day 62 for cyproconazole (rainbow trout) and at day 31 for propiconazole (fathead minnow).

†Predicted with von Bertalanffy growth model on the basis of in vitro cell proliferation experiments (5-day exposure).