Table 3 Genome-wide significant loci outside the MHC region and the top variant within the MHC region.

Bold font in the left half of the table indicates novel loci, whereas bold font in the right half indicates variants that replicated in Sardinians. All P values shown are two-sided. Gene names of known loci are as listed by Sawcer et al. (3). C, chromosome. For additional details, see table S4.

VariantCMAGeneMAF DEOR (CI) DE1 + DE2P DE1 + DE2P SardiniaOR (CI) DE + SardiniaP DE + Sardinia
rs107974311TMMEL134.10.84 (0.80–0.89)1.81 × 10−10
rs66894701AEVI514.21.24 (1.16–1.33)3.93 × 10−10
rs23007471GCD5812.40.75 (0.69–0.81)1.74 × 10−12
rs75358181GRGS119.20.76 (0.71–0.82)1.51 × 10−15
rs26814243CCD8649.70.86 (0.82–0.90)9.51 × 10−10
rs68592195AANKRD5522.20.84 (0.79–0.89)8.06 × 10−9
rs31043736THLA-DRB113.62.90 (2.72–3.09)1.34 × 10−234
rs43645066AL3MBTL326.40.84 (0.80–0.89)4.06 × 10−90.830.89 (0.85–0.93)1.99 × 10−6
rs218241010TIL2RA38.10.84 (0.79–0.88)1.15 × 10−11
rs189162110GIntergenic46.70.87 (0.83–0.91)2.94 × 10−8
rs180069312CTNFRSF1A42.11.17 (1.11–1.23)1.06 × 10−9
rs281219713TDLEU138.40.86 (0.82–0.91)9.95 × 10−96.86 × 10−30.87 (0.83–0.91)2.83 × 10−10
rs649816816TCLEC16A35.51.23 (1.17–1.29)1.98 × 10−15
rs3428659216TMAZ14.21.21 (1.13–1.30)4.58 × 10−80.441.16 (1.09–1.23)4.79 × 10-7
rs492516617TSHMT134.50.85 (0.81–0.90)2.69 × 10−95.63 × 10−40.86 (0.82–0.90)7.40 × 10−12
rs283642521TERG12.71.22 (1.14–1.31)2.84 × 10−80.351.18 (1.11–1.25)1.54 × 10−7