Table 2 Genome-wide significant HLA alleles.

Alleles are in order of stepwise logistic regression. For each row, alleles from the rows above have been used as covariates in the model. AF (allele frequency of controls in %) is calculated from a joint set of DE1 and DE2. ORs and P values are from a fixed-effects pooled analysis of DE1 and DE2.

HLA alleleAFOR (95% CI)PHLA alleles in LD (r2 > 0.9)
DRB1*15:0114.82.85 (2.66–3.06)1.03 × 10−191DQB1*06:02
A*02:0128.60.68 (0.64–0.73)3.68 × 10−29
B*38:012.00.36 (0.27–0.49)2.09 × 10−11
DRB1*13:031.51.96 (1.60–2.40)6.42 × 10−11
DPB1*03:0110.31.33 (1.22–1.46)4.35 × 10−10
DRB1*03:0112.21.29 (1.18–1.40)1.85 × 10−8DQA1*05:01, DQB1*02:01
DRB1*08:013.01.63 (1.39–1.91)2.36 × 10−9DQA1*04:01, DQB1*04:02