Alleles are in order of stepwise logistic regression. For each row, alleles from the rows above have been used as covariates in the model. AF (allele frequency of controls in %) is calculated from a joint set of DE1 and DE2. ORs and P values are from a fixed-effects pooled analysis of DE1 and DE2.
HLA allele | AF | OR (95% CI) | P | HLA alleles in LD (r2 > 0.9) |
DRB1*15:01 | 14.8 | 2.85 (2.66–3.06) | 1.03 × 10−191 | DQB1*06:02 |
A*02:01 | 28.6 | 0.68 (0.64–0.73) | 3.68 × 10−29 | |
B*38:01 | 2.0 | 0.36 (0.27–0.49) | 2.09 × 10−11 | |
DRB1*13:03 | 1.5 | 1.96 (1.60–2.40) | 6.42 × 10−11 | |
DPB1*03:01 | 10.3 | 1.33 (1.22–1.46) | 4.35 × 10−10 | |
DRB1*03:01 | 12.2 | 1.29 (1.18–1.40) | 1.85 × 10−8 | DQA1*05:01, DQB1*02:01 |
DRB1*08:01 | 3.0 | 1.63 (1.39–1.91) | 2.36 × 10−9 | DQA1*04:01, DQB1*04:02 |