Table 2 Physicochemical characterization of biodegradable NP.

Hydrodynamic diameter and PDI were measured by DLS. ζ-potential was measured at pH 7.4 in 10 mM NaCl. Mucus penetration indicates the ability of the NP to penetrate CF sputum, as determined by MPT in Fig. 2.

Particle typeDiameter (nm)PDIζ-Potential
(mV)
Mucus
penetration
PLGA141 ± 150.14−73 ± 4X
PLGA-PEG128 ± 60.09−6 ± 1O
PLGA/PF190 ± 70.09−64 ± 2X
PLGA/F68180 ± 170.09−23 ± 4X
PLGA/F127200 ± 80.14−8 ± 2O
DP/PLGA/F68150 ± 100.08−23 ± 1X
DP/PLGA/
F127
260 ± 210.10−4 ± 2O