Table 1 Genotypes of live offspring of crossing hSOD1G93A with different Tdp1 backgrounds.

Male mice overexpressing hSOD1G93A were bred with female WT mice, heterozygous for Tdp1 or homozygous for Tdp1 knockout. The live births were genotyped at 1 month postnatum.

Male parentParent hSOD1G93A Tdp1+/−
Female parentSod1+/+ Tdp1−/−Sod1+/+ Tdp1+/−Sod1+/+ Tdp1+/+
Offspring (no. of live births)ExpectedObtainedExpectedObtainedExpectedObtained
Sod1+/+ Tdp1+/+6.2532.250
Sod1+/+ Tdp1+/−54.5612.552.254
Sod1+/+ Tdp1−/−54.51156.2514
hSOD1G93A Tdp1+/+6.25142.255
hSOD1G93A Tdp1+/−54.59612.5122.250
hSOD1G93A Tdp1−/−54.51*6.252
Total218218505099
Male parenthSOD1G93A; Tdp1+/+
Female parentSod1+/+; Tdp1−/−Sod1+/+; Tdp1+/−Sod1+/+; Tdp1+/+
Offspring (no. of live births)ExpectedObtainedExpectedObtainedExpectedObtained
Sod1+/+; Tdp1+/+15.25976
Sod1+/+; Tdp1+/−24.52115.2515
Sod1+/+; Tdp1−/−
hSOD1G93A; Tdp1+/+15.252378
hSOD1G93A; Tdp1+/−24.52815.2514
hSOD1G93A; Tdp1−/−*
Total494961611414

*One fetus demised in utero.