Table 1 Clinical characteristics of the Berne Amish kindred by SERPINE1 genotype status.

Continuous values are listed as mean ± SD unless otherwise specified. HDL, high-density lipoprotein; LDL, low-density lipoprotein.

SERPINE1+/+
(n = 127)
SERPINE1+/−
(n = 43)
P*
Age (years)46 ± 2044 ± 170.97
Female, n (%)70 (55)28 (65)0.43
Hypertension, n (%)41 (33)14 (33)0.85
Systolic blood pressure (mmHg)130 ±18128 ± 200.69
Diastolic blood pressure (mmHg)77 ± 1078 ± 120.60
Obesity, n (%)38 (30)12 (28)0.60
Body mass index (kg/m2)27.7 ± 5.926.9 ± 6.30.29
Diabetes, n (%)8 (7)0 (0)<0.01
Fasting insulin (uIU/ml)4.9 (3.3–6.7)4.0 (2.9–5.1)0.04
Total cholesterol (mg/dl)188 ± 40188 ± 550.92
HDL cholesterol (mg/dl)60 ± 1563 ± 120.25
Triglyceride (mg/dl)81 (57–113)76 (51–110)0.54
LDL cholesterol (mg/dl)109 ± 32107 ± 440.67
Serum creatinine (mg/dl)0.80 ± 0.160.75 ± 0.150.13
Ever smoked, n (%)48 (38)12 (28)0.11

*Polygenic model adjusted for carrier status and family structure in SOLAR.

†Non-normally distributed, reported as median (25th to 75th percentile).