Table 3 Mediation analysis: DNAm and the association between famine exposure and triglycerides.
CpGLocation
(hg19)
Nearest
gene*
Methylation
(SD)
RankEWAS
PFDR
PfaminePTGPrevious
studies
βmediationP
mediation
Proportion
mediated (%)
[95% CI]§
Pproportion
cg19693031chr1:145441552TXNIP77.5 (4.3)62.6 × 10−54.8 × 10−32.3 × 10−11(4145)2.6 [0.7–4.8]0.00528.0 [5.7–100]0.026
cg18120259chr6:43894639LOC10013235460.4 (4.7)101.8 × 10−36.6 × 10−46.4 × 10−8(44)2.3 [0.8–4.1]0.00124.9 [7.5–100]0.021
cg15020801chr17:46022809PNPO36.1 (3.4)123.5 × 10−37.1 × 10−46.0 × 10−8(30)2.3 [0.9–4.2]0.00125 [7.0–100]0.022
cg06983052chr1:90288099LRRC8D64.8 (3.8)134.2 × 10−31.0 × 10−55.3 × 10−62.6 [1.1–4.5]<0.00128.0 [8.8–100]0.024
cg07397296chr21:43655316ABCG126.9 (3.8)140.0215.1 × 10−31.9 × 10−7(49)1.9 [0.6–3.6]0.00520.5 [4.6–97.4]0.027
cg20496314chr22:39759864SYNGR140.2 (4.3)150.0323.9 × 10−31.5 × 10−7(45, 46)1.8 [0.5–3.5]0.00719.6 [3.6–88.3]0.026

*Nearest gene within 100 kb.

†The Illumina 450k array β value (ranging from 0 to 1) multiplied by 100 for easy interpretation.

‡This is the estimate and CI based on 10K Monte Carlo simulations of the indirect effect or mediation effect, which is often referred to as the “a × b” effect.

§The percentage of the total exposure-phenotype relationship explained by the indirect (mediated) effect as based on 10K Monte Carlo simulations.