Table 1 Proteins with significantly changed abundance in skeletal muscle and adipose tissue in response to acute sleep loss in humans.

Proteins (A) up-regulated and (B) down-regulated in skeletal muscle (vastus lateralis muscle) and up-regulated in (C) subcutaneous adipose tissue in response to sleep loss compared with normal sleep. No proteins were found to be down-regulated in subcutaneous adipose tissue. Protein IDs shown are limited to 3. n = 15 pairs for each tissue; two-sided t tests.

Protein IDsProtein names (gene name in parentheses)Log2 ratio
(sleep loss/sleep)
A. Up-regulated proteins in skeletal muscle
O14558Heat shock protein beta-6 (HSPB6)0.330.430.012
P07195l-Lactate dehydrogenase B chain; l-lactate dehydrogenase (LDHB)0.370.510.017
P08238Heat shock protein HSP 90-beta (HSP90AB1)
P35609; P35609-2Alpha-actinin-2 (ACTN2)
Q2TBA0; Q2TBA0-2Kelch-like protein 40 (KLHL40)0.380.550.035
Q9GZV1Ankyrin repeat domain-containing protein 2 (ANKRD2)0.440.720.038
Q5XKP0Protein QIL1 (QIL1)
C9JFR7; P99999Cytochrome c (CYCS)0.210.320.042
O14949Cytochrome b-c1 complex subunit 8 (UQCRQ)0.230.370.049
B. Down-regulated proteins in skeletal muscle
O00757Fructose-1.6-bisphosphatase isozyme 2 (FBP2)−
Q9NR12-6PDZ and LIM domain protein 7 (PDLIM7)−0.310.350.005
P00558; P00558-2Phosphoglycerate kinase 1 (PGK1)−
Q9UKS6Protein kinase C and casein kinase substrate in neurons protein 3 (PACSIN3)−
P02585Troponin C, skeletal muscle (TNNC2)−0.270.320.012
P14543-2; P14543Nidogen-1 (NID1)−0.310.350.013
P14618-2Pyruvate kinase (PKM)−
Q08043Alpha-actinin-3 (ACTN3)−0.400.470.017
Q5T7C4; Q5T7C6; P09429High mobility group protein B1 (HMGB1)−
Q8N142; Q8N142-2Adenylosuccinate synthetase isozyme 1 (ADSSL1)−
P61586; Q5JR08; P08134Transforming protein RhoA; Rho-related guanosine
5′-triphosphate–binding protein RhoC (RHOA; RHOC)
P55786; P55786-2Puromycin-sensitive aminopeptidase (NPEPPS)−
Q14324Myosin-binding protein C, fast-type (MYBPC2)−0.370.560.026
P04075Fructose-bisphosphate aldolase A; Fructose-bisphosphate aldolase (ALDOA)−
P50995-2; P50995Annexin A11 (ANXA11)−0.330.280.028
P62942; Q5W0X3Peptidyl-prolyl cis-trans isomerase FKBP1A; peptidyl-prolyl
cis-trans isomerase (FKBP1A; FKBP12-Exip2)
P17612; P17612-2; P22694-4cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent
protein kinase catalytic subunit beta (PRKACA; PRKACB; KIN27)
P00338; P00338-3; P00338-4l-Lactate dehydrogenase A chain (LDHA)−0.210.310.036
P07108; P07108-3; P07108-2Acyl-CoA–binding protein (DBI)−
P12882Myosin-1 (MYH1)−0.931.380.038
P08237; P08237-3; P08237-26-Phosphofructokinase, muscle type (PFKM)−
P05976Myosin light chain 1/3, skeletal muscle isoform (MYL1)−
Q0VAK6; Q0VAK6-2Leiomodin-3 (LMOD3)−0.230.310.043
C. Up-regulated proteins in subcutaneous adipose tissue
P09211Glutathione S-transferase (GSTP)
P02788Lactotransferrin (LTF)0.950.260.004
P00558; P00558-2Phosphoglycerate kinase 1 (PGK1)