Table 1 The Ω-family peptides.

(Top) Names, sequences, and I_scores of all Ω-family peptides synthesized for this study. Note that pexiganan was used as a toxicity control. (Bottom) Sequence alignment between Ω76 and pexiganan. Despite some similarities, the two peptides display vastly different toxicological profiles, as described in the “In vitro and in vivo toxicity of designed AMPs” section.

PeptideSequenceI_score
Ω03KLGKKLRKKLKKIGKGLKAI3
Ω13KAIKRIGKRIKKLLLKLKKK5
Ω17RKKAIKLVKKLVKKLKKALK19
Ω76FLKAIKKFGKEFKKIGAKLK6
Ω93IKALGKKLRKGKKKIGKKVK1
PexigananGIGKFLKKAKKFGKAFVKILKKNot tested
Ω76-shuf1AFLLKKKKGIIFFEKAKKGKNot tested
Ω76-shuf2AKKKKFIFIKEKAFLLKGKGNot tested
Ω76-shuf3KKKKGFILILKEAFAFKKGKNot tested
Ω76-shuf4AKFKKEKILLFAKGKFIKGKNot tested
Ω76––––FLKAIKKFGKEFKKIGAKLK
PexigananGIGKFLKKAKKFGKAFVKILKK––