Table 1 List of unique and shared epitopes derived from common Influenza A and islet antigens for DQ8cis and DQ8trans.

Ins, insulin; ICA69, islet cell antigen 69.

Influenza A/New Caledonia/20/1999
Hemagglutinin
Influenza A/New York/318/2003
Nucleoprotein
PeptideSequencePeptideSequence
Shared and cross-reactive
between
DQ8cis and DQ8trans
Group I*HA102–118PENGTCYPGYFADYEELNP61–77LTIERMVLSAFDERRNK
HA108–124YPGYFADYEELREQLSSNP288–304GYDFEKEGYSLVGVDPF
HA114–130DYEELREQLSSVSSFERNP294–310EGYSLVGVDPFKLLQTS
HA120–136EQLSSVSSFERFEIFPKNP306–322LLQTSQVYSLIRPNENP
HA238–254DQEGRINYYWTLLEPGDNP468–484DERATNPIVPSFDMSNE
HA274–290SRGFGSGIITSNAPMDENP480–496DMSNEGSYFFGDNAEEY
HA280–296GIITSNAPMDECDAKCQNP486–498SYFFGDNAEEYDN
HA398–414VIEKMNTQFTAVGKEFN
HA404–420TQFTAVGKEFNKLERRM
HA434–450IWTYNAELLVLLENERT
Group IIHA440–456ELLVLLENERTLDFHDSNP240–256DQVRESRNPGNAEIEDL
Group IIIHA186–202EKEVLVLWGVHHPPNIGNP175–191RSGAAGAAVKGVGTMVL
Unique epitopes for DQ8cisHA452–468DFHDSNVKNLYEKVKSQ
InconclusiveHA340–356IQSRGLFGAIAGFIEGG
HA422–438NLNKKVDDGFLDIWTYN
Islet antigens
PeptideSequence
Shared and cross-reactive
between
DQ8cis and DQ8trans
GAD65121–140§YVVKSFDRSTKVIDFHYPNE
GAD65250–266§AMMIARFKMFPEVKEKG
InsB11–24§LVEALYLVCGERGF
IA-2168–182GASSSLSPLQAELLP
IA-2273–287FQDSGLLYLAQELPA
IA-2761–777RSDYINASPIIEHDPRM
IA-2957–972DQFEFALTAVAEEVNA
ICA69297–311QEPSQLISLEEENQR
IGRP306–320LYHFLQIPTHEEHLF
Phogrin323–337GLSGLELDGMAELMA
ZnT815–29AKMYAFTLESVELQQ

*In vitro responses detected by both DQ8cis and DQ8trans tetramers.

†In vitro responses detected only by DQ8cis tetramers.

‡In vitro responses detected only by DQ8trans tetramers.

§Epitopes reported in our previous studies.