Table 2 Incidence and detection rate of leukocoria in photographs collected by parents of 20 test children and 20 healthy control children (iPhone X).

N/A, not applicable.

Unilateral retinoblastoma
(n = 8)
Bilateral retinoblastoma
(n = 7)
Coats’ disease, cataract,
amblyopia, hyperopia
(n = 5)
Healthy control
(n = 20)*
Average age at diagnosis
(days)
4021141277N/A
Average age of detection by
CRADLE prototype (days)
11775276N/A
No. of photographs collected90657129705429,734
No. of leukocoric photographs
collected
444927304144
No. of leukocoric photographs
detected
by CRADLE
1382897281
No. of leukocoric photographs
collected before diagnosis
261293232N/A
No. of leukocoric photographs
detected by CRADLE before
diagnosis
748756N/A
ITP rate31.08%31.18%23.68%56.25%
IFP rate0.75%0.61%0.33%0.79%

*Data listed for 20 control children without an eye disorder. Eight of 20 control children did not exhibit physiologic leukocoria during the time period of photography. Table S8 lists personalized values for each control child.

†Sum of all facial photographs (with open eyes) collected from each patient from each respective category.

‡Rates of intrinsic true positive (TP) and FP leukocoria detection refer to the average true or false detection of leukocoria by CRADLE per photograph (see table S7 for personalized values for each test child).