Table 2 Summary of conditional analysis using outcomes from UKB.

Summary of conditional analysis using outcomes from UKB.. Joint models refer to the estimated joint effects of all selected SNPs in a region (i.e., all independent SNPs are fitted together).

Primary signalChrSNPNearest
gene
PositionRef
allele
Ref allele
frequency
βSEPJoint βJoint SEJoint P
rs131073254rs13107325SLC39A8103188709C0.9280.1110.0201.6 × 10−80.1120.0201.4 × 10−8
rs131073254rs13116422NFKB1103387160T0.9160.0910.0191.9 × 10−60.0920.0191.7 × 10−6
Extended analysis of 4.q23 region containing ADH1B (rs1229984) and BTF3P13 loci (rs144198753)
4rs1229984ADH1B100239319T0.020−0.4550.0363.3 × 10−36−0.4670.0368.7 × 10−38
4rs551676206ADH5100019089A0.9900.5140.0536.2 × 10−220.5280.0546.1 × 10−23
4rs62307263ADH1A100167112C0.8990.0830.0171.1 × 10−60.1690.0231.9 × 10−13
4rs140859990TSPAN599456373G0.937−0.1020.0212.0 × 10−6−0.1020.0211.9 × 10−6
4rs182381822ADH4100179872T0.993−0.2740.0697.2 × 10−5−0.3440.0697.1 × 10−7
4rs1800761ADH4100065593T0.183−0.0460.0130.00054−0.4010.0345.3 × 10−33
4rs200411287ADH4100078163A0.851−0.0230.0150.12−0.5200.0384.4 × 10−42
4rs150187763EIF4E99801016A0.9820.0100.0390.79−0.3130.0472.8 × 10−11