Table 1 Summary of validated associations that meet genome-wide significance in the meta-analysis of UKB and GERA, which also demonstrate nominal association with the same direction of effect in GERA.

OR, odds ratio; CI, confidence interval.

UKB heavy alcohol drinker status (cases versus controls)GERA (replication)
drinks/week (among
drinkers)
Meta-
analysis
ChrPositionLead SNPLocusRisk alleleOther alleleRAFOR
(95% CI)
Pβ (SE)PP
227730940rs1260326GCKRCT0.6121.06
(1.04–1.08)
2.6 × 10−80.033
(0.029)
1.1 × 10−61.5 × 10−13
439422242rs13130794KLBTC0.6321.07
(1.05–1.09)
2.6 × 10−100.035
(0.007)
4.2 × 10−75.7 × 10−16
499713350rs144198753BTF3P13CT0.9911.66
(1.48–1.85)
2.70 × 10−180.156
(0.023)
2.1 × 10−114.1 × 10−29
4100239319rs1229984ADH1BCT0.9801.58
(1.48–1.70)
3.30 × 10−360.187
(0.016)
2.9 × 10−322.3 × 10−66
4103188709rs13107325SLC39A8CT0.9281.12
(1.08–1.16)
1.60 × 10−80.029
(0.013)
0.02496.7 × 10−9
11113316102rs11214609DRD2GC0.3951.06
(1.04–1.08)
2.10 × 10−70.021
(0.007)
0.00354.30 × 10−9