Table 1 Known cancer driver genes amplified in eccDNA/gene duplications (JTGE1) in various tumor types.

ACCFGFR2, H3F3A, FOXA1, SMARCA4, NFE2L2, PMS1, SF3B1, SOS1, PCBP1, KIT, EGFR, GNAQ
BLCAERCC2, GRIN2D, PPP2R1A, SOS1, PCBP1, MSH3
BRCAFGFR2, MTOR, WT1, SF1, CCND1, PTPRC, PTPN11, KRAS, H3F3A, ERBB3, KLF5, MACF1, AKT1, FOXA1, MAP2K1, IDH2, ERBB2, SPOP,
SETBP1, SMARCA4, CACNA1A, PIK3R2, GNA11, ERCC2, GRIN2D, PPP2R1A, U2AF1, NFE2L2, PMS1, SF3B1, IDH1, MAPK1, SOS1,
PCBP1, CTNNB1, RHOA, FBXW7, KIT, MSH3, PIK3CG, UNCX, BRAF, CUL1, EGFR, GTF2I, MYC, SOX17, GNAQ, EIF1AX
CESEMTOR, PTPRC, H3F3A, NFE2L2, PMS1, GNAQ
COADFGFR2, MTOR, WT1, SF1, CCND1, PTPRC, KRAS, H3F3A, ERBB3, CDK4, CHD4, ARID1A, KLF5, MACF1, FOXA1, MAP2K1, IDH2, ERBB2,
SPOP, SETBP1, SMARCA4, CACNA1A, PIK3R2, GNA11, ERCC2, GRIN2D, PPP2R1A, GNAS, U2AF1, NFE2L2, PMS1, SF3B1, IDH1,
MAPK1, PLXNB2, SOS1, PCBP1, PIK3CA, CTNNB1, RHOA, MSH3, EEF1A1, PIK3CG, BRAF, CUL1, EGFR, GTF2I, SOX17, GNAQ,
EIF1AX
ESCAFGFR2, CCND1, PTPN11, KRAS, ERBB3, CDK4, KLF5, FOXA1, MAP2K1, IDH2, ERBB2, SETBP1, NFE2L2, PMS1, SF3B1, IDH1, SOS1, PCBP1,
PIK3CA, CTNNB1, RHOA, KIT, MSH3, EEF1A1, EGFR, GTF2I, MYC, SOX17
GBMH3F3A, CDK4, PIK3R2, ERCC2, GRIN2D, EGFR, MYC
HNSCFGFR2, MTOR, SF1, CCND1, PTPRC, KRAS, ERBB3, CDK4, KLF5, MAP2K1, ERBB2, SPOP, SETBP1, KEAP1, SMARCA4, CACNA1A, PIK3R2,
ERCC2, GRIN2D, NFE2L2, PMS1, SF3B1, IDH1, PCBP1, PIK3CA, EGFR, GTF2I, MYC, GNAQ
KIRCFGFR2, MTOR, WT1, PTPRC, KRAS, ERBB3, CDK4, FOXA1, MAP2K1, ERBB2, SPOP, SMARCA4, CACNA1A, PIK3R2, ERCC2, GRIN2D,
PPP2R1A, NFE2L2, PMS1, SF3B1, IDH1, MAPK1, SOS1, PCBP1, PIK3CG, RAC1, SOX17
KIRPFGFR2, PTPRC, FOXA1, IDH2, ERBB2, SPOP, SMARCA4, ERCC2, GRIN2D, PPP2R1A, MAPK1, SMARCB1, PCBP1, PIK3CA, MSH3, PIK3CG,
MET, BRAF, CUL1, EGFR, MYC, SOX17, GNAQ
LGGWT1, MACF1, PCBP1, KIT, PIK3CG, MTOR
LIHCWT1, SF1, CCND1, DHX9, PTPRC, PTPN11, KRAS, CHD4, MACF1, MAP2K1, ERBB2, SPOP, SETBP1, SMARCA4, CACNA1A, PIK3R2,
GNA11, ERCC2, GRIN2D, U2AF1, PMS1, SF3B1, IDH1, SOS1, XPO1, PCBP1, PIK3CA, KIT, CDKN1A, EEF1A1, PIK3CG, BRAF, CUL1,
GNAQ, EIF1AX
LUADFGFR2, MTOR, WT1, SF1, CCND1, PTPRC, KRAS, H3F3A, ERBB3, CDK4, KLF5, MACF1, MAP2K1, ERBB2, SPOP, SETBP1, SMARCA4,
CACNA1A, PIK3R2, GNA11, ERCC2, GRIN2D, PPP2R1A, NFE2L2, PMS1, SF3B1, IDH1, SOS1, PCBP1, CTNNB1, RHOA, MSH3, EEF1A1,
RAC1, GTF2I, MYC
LUSCNRAS, PTPN11, KRAS, H3F3A, ERBB3, CDK4, ERCC2, GRIN2D, PPP2R1A, U2AF1, SF3B1, IDH1, SOS1, PCBP1, FGFR3, MSH3, GNAQ
MESOFGFR2, PTPRC, PTPN11, ERCC2, GRIN2D, PPP2R1A, IDH1, CTNNB1, RHOA, PIK3CG, RAC1, GTF2I, MYC
PCPGMTOR, NRAS, PTPRC, PMS1, SF3B1, IDH1, SOS1, EPAS1, PIK3CG, EGFR, MYC, SOX17
PRADMTOR, KRAS, ERBB3, CDK4, CHD4, KLF5, FOXA1, ERBB2, SPOP, TP53, SETBP1, SMARCA4, CACNA1A, PIK3R2, GNA11, ERCC2, GRIN2D,
PPP2R1A, NFE2L2, PMS1, SF3B1, IDH1, SOS1, PCBP1, KIT, MSH3, PIK3CG, EGFR, GTF2I, MYC, SOX17
SKCMCCND1, KRAS, CHD4, FOXA1, SETBP1, SMARCA4, CACNA1A, PIK3R2, ERCC2, GRIN2D, PPP2R1A, MAPK1, CTNNB1, RHOA, EGFR,
EIF1AX
STADMTOR, NRAS, WT1, SF1, CCND1, KRAS, H3F3A, ERBB3, CDK4, MAP2K1, ERBB2, SPOP, SETBP1, SMAD4, SMARCA4, CACNA1A, PIK3R2,
GRIN2D, NFE2L2, PMS1, SF3B1, IDH1, SOS1, PCBP1, PIK3CA, CTNNB1, RHOA, MSH3, CUL1, EGFR, GTF2I, MYC, SOX17, CNBD1, GNAQ,
FAM46D
TGCTWT1, KRAS, CHD4, MACF1, MAP2K1, IDH2, SETBP1, ERCC2, GRIN2D, PPP2R1A, SOS1, CTNNB1, SOX17, EIF1AX
THCANRAS, KLF5, ERBB2, SPOP, ERCC2, GRIN2D, PPP2R1A, PCBP1, CTNNB1, RHOA, PIK3CG, GTF2I
UCECCCND1, KLF5, ERBB2, SPOP, PIK3R2, U2AF1, PCBP1, PIK3CA, PIK3CG