Table 1 Characterization of POx micelles coloaded with anticancer agent and chemosensitizers.

Characterization of POx micelles coloaded with anticancer agent and chemosensitizers.. LE, loading efficiency; LC, loading capacity; PDI, polydispersity index.

Checkpoint kinase inhibitor (AZD7762) and anticancer agent (C6CP)
Feeding ratio
(g/liter)
LE (%)LC (%)Drug concentration in
solution (g/liter)
Deff (nm)PDI
C6CP/
AZD7762/
POx
C6CPAZD7762C6CPAZD7762TotC6CPAZD7762
8/0/1071.336.35.7124 ± 0.50.05 ± 0.05
0/8/1073.837.15.964 ± 3.60.64 ± 0.02
4/8/1052.577.511.533.945.42.16.225 ± 0.80.42 ± 0.02
6/6/1040.070.014.525.339.82.44.282 ± 4.70.45 ± 0.07
8/4/1038.880.019.019.638.63.13.2128 ± 0.70.09 ± 0.02
9/3/1058.990.029.415.044.45.32.7112 ± 1.10.09 ± 0.02
ATR inhibitor (VE-822) and anticancer agent (C6CP)
Feeding ratio
(g/liter)
LE (%)LC (%)Drug concentration in
solution (g/liter)
Deff (nm)PDI
C6CP/VE-822/
POx
C6CPVE-822C6CPVE-822TotC6CPVE-822
8/0/1098.844.07.9122 ± 0.90.10 ± 0.03
0/8/1083.840.06.7351 ± 6.70.40 ± 0.08
4/8/1092.575.018.830.549.33.76.0354 ± 4.70.50 ± 0.02
6/6/1091.783.326.824.451.25.55.0240 ± 1.90.30 ± 0.01
8/4/1096.385.036.516.152.67.73.4211 ± 3.80.30 ± 0.02
9/3/109190.039.213.052.28.22.7160 ± 2.40.20 ± 0.01