Table 1 MICs (μg/ml) of different antibiotics for the single and multiple P. aeruginosa PA14 mutants used in this work.

MICs ≥2-fold of the MICs for the wild-type PA14 strain are highlighted in bold. TOB, tobramycin; TGC, tigecycline; CAZ, ceftazidime; CIP, ciprofloxacin; IPM, imipenem.

	TOB	TGC	CAZ	CIP	IPM
PA14	1	6	1	0.094	0.75
*nfxB177*	1	32	1.5	3	1
*parR87*	1.5	8	1	0.125	2
*orfN50*	3	32	3	0.19	2
*nuoD184*	2	4	1	0.047	0.75
*mexZ43*	1.5	8	1	0.38	1.5
MDR6*	2	48	1.5	0.19	1.5
MDR12^†	32	64	1	0.5	1.5

*MDR6 mutant presents mutations in nfxB, phoQ, frr, and pmrB.

†MDR12 mutant presents mutations in fusA, orfN, pmrB, mexZ, gabP, ptsP, and nuoD.