Table 1 MICs (μg/ml) of different antibiotics for the single and multiple P. aeruginosa PA14 mutants used in this work.

MICs ≥2-fold of the MICs for the wild-type PA14 strain are highlighted in bold. TOB, tobramycin; TGC, tigecycline; CAZ, ceftazidime; CIP, ciprofloxacin; IPM, imipenem.

TOBTGCCAZCIPIPM
PA141610.0940.75
nfxB1771321.531
parR871.5810.1252
orfN5033230.192
nuoD1842410.0470.75
mexZ431.5810.381.5
MDR6*2481.50.191.5
MDR12326410.51.5

*MDR6 mutant presents mutations in nfxB, phoQ, frr, and pmrB.

†MDR12 mutant presents mutations in fusA, orfN, pmrB, mexZ, gabP, ptsP, and nuoD.