Table 2 Summary of serum biochemistry values in healthy dogs before and after oral PLGA-GA2-CUR administration.

GA2-CUR administration. A/G ratio, albumin-to-globulin ratio; BUN, blood urea nitrogen; ALKP, alkaline phosphatase; AST, aspartate aminotransaminase; ALT, alanine aminotransaminase; GGT, gamma-glutamyl transferase; GLDH, glutamate dehydrogenase.

Chemistry profileBefore dosing24 hours after dosing
PLGA-GA2-CUR
7 days after dosing
PLGA-GA2-CUR
Reference range
Total protein (g/dl)5.33 ± 0.155.03 ± 0.105.13 ± 0.105.6–7.9
Albumin (g/dl)2.98 ± 0.172.93 ± 0.053.05 ± 0.062.8–4.3
Globulins (g/dl)2.35 ± 0.192.10 ± 0.082.08 ± 0.051.8–4.2
A/G ratio1.30 ± 0.181.40 ± 0.081.48 ± 0.050.7–2.5
Calcium (mg/dl)10.75 ± 0.3410.48 ± 0.2610.63 ± 0.137.2–12.8
Phosphorus (mg/dl)7.45 ± 0.706.93 ± ±0.547.03 ± 0.212.3–6.5
Glucose (mg/dl)73.00 ± 10.30100.00 ± 6.88106.25 ± 6.7060–120
BUN (mg/dl)14.25 ± 1.2612.75 ± 1.0510.25 ± 1.508–30
Creatinine (mg/dl)0.53 ± 0.050.58 ± 0.100.63 ± 0.050.5–1.4
Bilirubin–total (mg/dl)0.15 ± 0.100.20 ± 0.080.15 ± 0.060.1–0.4
ALKP (U/liter)108.50 ± 25.72107.25 ± 16.66103.50 ± 16.6012–122
AST (U/liter)46.25 ± 4.7935.25 ± 1.5040.50 ± 2.6513–52
ALT (U/liter)34.50 ± 3.7032.50 ± 5.3237.75v7.4113–79
GGT (U/liter)4.25 ± 1.262.50 ± 0.713.25 ± 0.500–10
GLDH (U/liter)8.50 ± 1.917.75 ± 0.966.50 ± 1.290–14
Amylase (U/liter)592.00 ± 93.03590.00 ± 115.86605.50 ± 47.76200–953
Cholesterol (mg/dl)172.75 ± 18.52164.50 ± 20.86160.50 ± 17.71124–335
Sodium (mEq/liter)146.75 ± 1.71145.75 ± 0.50146.00 ± 1.63141–156
Potassium (mEq/liter)5.18 ± 0.384.75 ± 0.131.93 ± 0.133.8–5.5
Chloride (mEq/liter)107.50v0.58109.50 ± 0.58109.50 ± 0.58109–124
Sodium-to-potassium ratio28.45 ± 1.8330.70 ± 0.8629.65 ± 0.82