Table 1 Summary of hematology values in healthy dogs before and after oral PLGA-GA2-CUR administration.

WBC, white blood cells; Abs, absolute; Rel, relative; RBC, red blood cell; HGB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RDW, red cell distribution width; PLT, platelet; MPV, mean platelet volume; PCT, procalcitonin; Retic, reticulocyte; Retic abs count, absolute reticulocyte count.

CBC whole bloodBefore dosing24 hours after dosing PLGA-GA2-CUR7 days after dosing PLGA-GA2-CURReference range
Total WBC (K/μl)13.46 ± 310.79 ± 2.3511.5 ± 1.366.0–17.0
Abs neutrophils (K/μl)8.93 ± 2.946.00 ± 1.46.98 ± 1.533.0–11.5
Abs lymphocytes (K/μl)3.7 ± 0.463.95 ± 1.043.33 ± 0.811.0–4.8
Abs monocytes (K/μl)0.57 ± 0.420.6 ± 0.290.9 ± 0.220.15–1.35
Abs eosinophils (K/μl)0.27 ± 0.060.3 ± 0.10.25 ± 0.170.10–1.25
Rel neutrophils (%)65.33 ± 6.8155.5 ± 1.2960.5 ± 8.58
Rel lymphocytes (%)29 ± 9.5436.25 ± 2.8729.25 ± 7.63
Rel monocytes (%)4.00 ± 3.006.25 ± 3.778.00 ± 2.00
Rel eosinophils (%)3.67 ± 0.583.46 ± 1.652.25 ± 1.26
RBC (M/μl)5.94 ± 0.278.08 ± 3.766.54 ± 0.275.5–8.5
HGB (g/dl)10.6 ± 4.8120.35 ± 12.7715.13 ± 0.9312.0–18.0
HCT (%)28.1 ± 13.946.9 ± 13.9743.55 ± 0.8632–55
MCV (fl)51.17 ± 16.6954.23 ± 20.6966.68 ± 3.3660–77
MCH (pg)35.8 ± 23.1325.6 ± 6.1723.15 ± 0.9319.5–24.5
MCHC (g/dl)32.53 ± 7.6829.73 ± 10.4934.73 ± 0.3832–36
RDW (%)22.63 ± 13.2215.15 ± 1.514.63 ± 01.5911.9–14.9
PLT (K/μl)445.4 ± 66.72444.33 ± 21.95521.25 ± 79.28200–500
MPV (fl)9.00 ± 3.897.46 ± 5.139.9 ± 1.757.9–16.2
PCT (%)3.27 ± 4.70.53 ± 0.20.52 ± 0.150.12–0.43
Retic (%)0.66 ± 0.340.94 ± 0.611.39 ± 0.84
Retic abs count (K/μl)43.46 ± 14.3041.4 ± 22.750.66 ± 11.4210–80