Table 1 Correlations of NAbs-Aβ with the rate of PACC decline in the total cohort and the Aβ-PET+ subgroup.

Note: Linear mixed models with adjustment of age, gender, education level, and APOE ε4 genotype.

Parameterβ (SE) unadjustedP values (unadjusted)β (SE) adjustedP values (adjusted)
Total cohort
NAbs-Aβ1–12Biomarker−1.52 (0.36)3.23 × 10−5*−0.903 (0.325)0.00576
NAbs-Aβ7–18Biomarker−0.834 (0.378)0.0279−0.369 (0.332)0.267
NAbs-Aβ13–24Biomarker0.355 (0.269)0.1880.558 (0.232)0.0166
NAbs-Aβ19–30Biomarker2.32 (0.393)8.14 × 10−9*1.89 (0.345)8.07 × 10−8*
NAbs-Aβ25–36Biomarker2.62 (0.394)1.17 × 10−10*2.28 (0.343)1.19 × 10−10*
NAbs-Aβ31–42Biomarker0.288 (0.606)0.6351.02 (0.523)0.051
NAbs-Aβ1–42Biomarker−0.245 (0.179)0.172−0.117 (0.155)0.451
NAbs-Aβ1–12Time0.03 (0.019)0.1160.0227 (0.019)0.234
NAbs-Aβ7–18Time0.016 (0.0187)0.3940.0167 (0.0187)0.373
NAbs-Aβ13–24Time−0.00526 (0.0167)0.7522.51 × 10−5 (0.017)0.999
NAbs-Aβ19–30Time−0.0256 (0.0311)0.412−0.0053 (0.0312)0.866
NAbs-Aβ25–36Time0.0291 (0.0316)0.3580.0504 (0.0316)0.113
NAbs-Aβ31–42Time−0.0147 (0.011)0.18−0.00896 (0.011)0.415
NAbs-Aβ1–42Time−0.0136 (0.0192)0.479−0.0084 (0.0193)0.663
NAbs-Aβ1–12Biomarker × Time−0.181 (0.059)0.00248−0.139 (0.059)0.0198
NAbs-Aβ7–18Biomarker × Time−0.13 (0.0573)0.0249−0.114 (0.0573)0.0484
NAbs-Aβ13–24Biomarker × Time−0.0481 (0.0415)0.248−0.0474 (0.0415)0.254
NAbs-Aβ19–30Biomarker × Time0.00985 (0.0645)0.879−0.0248 (0.0647)0.702
NAbs-Aβ25–36Biomarker × Time−0.109 (0.0642)0.0916−0.143 (0.0642)0.0269
NAbs-Aβ31–42Biomarker × Time−0.0875 (0.0855)0.307−0.0943 (0.0856)0.272
NAbs-Aβ1–42Biomarker × Time−0.0112 (0.0251)0.656−0.0109 (0.0252)0.667
Aβ-PET+ group
NAbs-Aβ1–12Biomarker−1.96 (0.659)0.00341−1.71 (0.603)0.00514
NAbs-Aβ7–18Biomarker−1.21 (0.707)0.088−0.694 (0.643)0.282
NAbs-Aβ13–24Biomarker0.831 (0.497)0.09661.18 (0.439)0.00801
NAbs-Aβ19–30Biomarker3.7 (0.747)1.65 × 10−6*3.02 (0.694)2.32 × 10−5*
NAbs-Aβ25–36Biomarker3.77 (0.765)1.82 × 10−6*3.38 (0.694)2.41 × 10−6*
NAbs-Aβ31–42Biomarker−0.28 (1.23)0.8210.211 (1.1)0.848
NAbs-Aβ1–42Biomarker−0.259 (0.372)0.487−0.112 (0.333)0.736
NAbs-Aβ1–12Time−0.0098 (0.0582)0.867−0.0183 (0.0576)0.751
NAbs-Aβ7–18Time0.0199 (0.0537)0.7110.0177 (0.0533)0.74
NAbs-Aβ13–24Time−0.11 (0.042)0.00985−0.102 (0.0416)0.0159
NAbs-Aβ19–30Time−0.287 (0.0877)0.00128*−0.273 (0.0864)0.00187*
NAbs-Aβ25–36Time0.0209 (0.0887)0.8140.0237 (0.0872)0.786
NAbs-Aβ31–42Time−0.0929 (0.0298)0.00225−0.0895 (0.0296)0.00295
NAbs-Aβ1–42Time0.0578 (0.047)0.2210.0557 (0.0466)0.233
NAbs-Aβ1–12Biomarker × Time−0.282 (0.177)0.114−0.248 (0.175)0.159
NAbs-Aβ7–18Biomarker × Time−0.362 (0.155)0.0212−0.35 (0.154)0.0248
NAbs-Aβ13–24Biomarker × Time0.0435 (0.0967)0.6540.0246 (0.0961)0.799
NAbs-Aβ19–30Biomarker × Time0.433 (0.195)0.02730.402 (0.191)0.0369
NAbs-Aβ25–36Biomarker × Time−0.259 (0.196)0.187−0.262 (0.192)0.175
NAbs-Aβ31–42Biomarker × Time−0.00977 (0.266)0.971−0.034 (0.264)0.898
NAbs-Aβ1–42Biomarker × Time−0.205 (0.0561)0.000357*−0.201 (0.0558)0.000426*

*Less than Bonferroni-corrected α. (α = 0.002). P < 0.05 were expressed as boldface.